10 Best Ant Killers 2025 in the United States

The Ortho Home Defense Insect Killer is a versatile spray designed to handle a wide range of household insects, including ants, making it a good choice for an all-around pest control solution rather than just an ant-specific product. It offers protection for up to 12 months indoors on non-porous surfaces, which provides impressive long-term prevention. You can use it both inside your home—in kitchens, bathrooms, and around entry points—and outside around your foundation or patio, giving you flexible options for tackling ants wherever they appear.

The Hot Shot Pest Control Fogger is designed mainly for indoor use and targets a wide range of insects, including ants, roaches, and spiders. Its active ingredients, Tetramethrin and Cypermethrin, work quickly to kill bugs on contact and continue killing for up to two months, which makes it helpful for heavy infestations. The fogger creates a fine mist that can reach into cracks and hidden areas where ants often hide, increasing its effectiveness. One useful feature is that it doesn’t leave a messy, wet residue and the clear mist won’t stain surfaces. Each can covers about 2,000 cubic feet, which is suitable for treating larger rooms or smaller whole-house applications in enclosed spaces like basements or garages.

The Ortho Orthene Fire Ant Killer is designed specifically to tackle fire ant problems outdoors by killing the queen and destroying the entire mound. It starts working within about an hour, allowing you to restore your yard quickly. The product comes as granules that you sprinkle directly over ant mounds—no need to water it in, making application straightforward.