10 Best Lip Wrinkle Treatments 2025 in the United States

This RoC Derm Correxion bundle combines a lip plumper peptide treatment with a retinol firming serum stick, catering to those looking to reduce lip wrinkles and improve lip volume. The lip volumizer uses peptides, hyaluronic acid, and vitamin E—ingredients known for hydration and skin repair—to provide fuller, more hydrated lips within minutes and noticeable volume improvement after weeks. The hydration lasts up to 48 hours, which is good for daily wear.

The Elizabeth Arden Retinol + HPR Ceramide Rapid Skin Renewing Water Cream is designed as a gentle yet effective wrinkle treatment suitable for both day and night use, making it a good choice for those new to retinol products. It contains powerful active ingredients like 2% retinol, niacinamide, hyaluronic acid, ceramides, and peptides. This combination helps reduce wrinkles, minimize pores, and improve skin texture and firmness. Importantly, it’s formulated to be gentle and irritation-free, supported by consumer studies indicating high comfort even for first-time retinol users. The cream is a lightweight, non-comedogenic moisturizer, which means it won’t clog pores and can be used on various skin types, especially aging skin.

StriVectin DoubleFix For Lips is a cream designed to target fine vertical lines and wrinkles around the mouth while also plumping and hydrating the lips. It works for all skin types and offers a no-sting formula, which is great if you have sensitive skin or dislike irritating treatments. Users can expect an instant boost in lip fullness and moisture, along with a subtle glossy finish that enhances natural lip color. The product claims visible improvement in stubborn vertical lines within about 4 weeks of use, which is a reasonable time frame for skin treatments.